There's an episode of EconTalk in which Gary Taubes—author of The Case Against Sugar—argues that reducing the problem to caloric deficit is analogous to simplifying the secret behind Bill Gate's wealth to “he made more money than he spent.”
forrestbrazeal.com/2017/12/0…
It took me more than 6 months, in my third attempt, to finish GEB. It's only one of the 101 books the author has read in last year, alongside Anna Karenina. Impressive.