Old, but worth a repost . I was very much influenced by @mattmight's "least resistance" philosophy. Also, I appreciate the no-nonsense view on the basic biology of weight loss. matt.might.net/articles/leas…
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I have been trying to learn more about nutrition. I was most shocked by these recent findings on artificial sweeteners: nature.com/articles/nature13… ncbi.nlm.nih.gov/pmc/article… It seems that modifying gut microbiome can mess with weight in spite of calorie count.

The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in...

Artificial sweeteners have been widely used in the modern diet, and their observed effects on human health have been inconsistent, with both beneficial and adverse outcomes reported. Obesity and type...

ncbi.nlm.nih.gov
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That's for sure interesting stuff, and I do think it's worth taking seriously. That said, I do think Matt has the right big picture story: weight loss is mostly about caloric deficit.
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