Jokes aside, the standard Nuzlocke rules might not be quite compatible, but I'd be up for the community agreeing to an adjusted ruleset that makes Arceus more fun.

Catch one pokemon for every region name. Easy peasy

I am interested to see what rules people set for this game, jokes aside. Like will each different designated section on a map count as a ‘new’ area for a catch? It’d have to since one per map would be too few Pokemon.

It's already been done

if you die in the game you die in real life

ive wondered how it would work

Friggin Powerful

The real hard one is the Professor Oak challenge